The efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial

To evaluate whether the immunomodulatory drug thymosin α1 reduces mortality in adults with sepsis. Multicentre, double blinded, placebo controlled phase 3 trial. 22 centres in China, September 2016 to December 2020. 1106 adults aged 18-85 years with a diagnosis of sepsis according to sepsis-3 criteria and randomly assigned in a 1:1 ratio to receive thymosin α1 (n=552) or placebo (n=554). A stratified block method was used for randomisation, and participants were s…