Dihexa
OtherAlso known as PNB-0408, N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide
Evidence tier
Multiple human trials
1 review
- Researched since
- 2013
- Publications
- 12
- Mean purity
- —
- Vendors listing
- 3
No indexed vendor publishes certificate records for Dihexa that this index could read yet, so no purity comparison is possible.
Score breakdown
The score has two halves: the research base — how long the compound has been studied and how much has been published — and the quality of the evidence the market produces for it, aggregated across every vendor that carries it: assayed purity, lot-to-lot consistency, readable third-party certificates and those vendors’ review record. It measures the evidence base, not the merits or safety of the substance.
Studied since 2013 — 13 years of published research
How long the compound has been studied. Fifteen years or more of published literature earns full marks; a newer compound earns less.
12 publications indexed in PubMed
The volume of published literature located. Full marks at fifty or more publications.
No certificate records indexed yet — nothing recorded yet
Average assayed purity on the certificates published by vendors that carry this compound. Full marks at 99.5%+, nothing at 95% or below.
No certificate records indexed yet — nothing recorded yet
How tightly assayed purity and labeled-versus-actual mass hold across different lots. Rewards reproducible manufacturing.
3 of 3 listing vendors publish an accessible certificate policy
Whether the vendors carrying this compound publish per-lot certificates anyone can read without an account.
No certificate records indexed yet — nothing recorded yet
Share of certificates issued by a recognised third-party testing lab rather than an unnamed or self-named one.
What is Dihexa?
A small peptide derivative studied for effects on synaptic connections and neurotrophic signalling in models of cognition. It is supplied as a research compound.
Studied in published research for cognition, memory and neuroprotection.
Regulatory status
Labeled by vendors for laboratory research use only. Not approved as a medicine in the United States, United Kingdom, or European Union.
What the research examines
The areas of published research this compound appears in. These describe what the literature has studied — never a claim of benefit, effect or suitability for any use.
Published research
Published work is preclinical, in cell and animal models of learning and memory. PepIndex does not evaluate clinical significance and does not describe administration.
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions — Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews (2026)
Peer-reviewed article indexed in PubMed, published in Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews (2026).
- Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies — Neuroscience and biobehavioral reviews (2018)
Peer-reviewed article indexed in PubMed, published in Neuroscience and biobehavioral reviews (2018).
- The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's Disease — Journal of Alzheimer's disease : JAD (2015)
Peer-reviewed article indexed in PubMed, published in Journal of Alzheimer's disease : JAD (2015).
- Small-Molecule-Directed Hepatocyte-Like Cell Differentiation of Human Pluripotent Stem Cells — Current protocols in stem cell biology (2016)
Peer-reviewed article indexed in PubMed, published in Current protocols in stem cell biology (2016).
- Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents — The Journal of pharmacology and experimental therapeutics (2013)
Peer-reviewed article indexed in PubMed, published in The Journal of pharmacology and experimental therapeutics (2013).
- Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy — Stem cell research & therapy (2022)
Peer-reviewed article indexed in PubMed, published in Stem cell research & therapy (2022).
- Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure — Frontiers in cellular neuroscience (2015)
Peer-reviewed article indexed in PubMed, published in Frontiers in cellular neuroscience (2015).
- The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases — Progress in neurobiology (2015)
Peer-reviewed article indexed in PubMed, published in Progress in neurobiology (2015).
Indexed studies1 human-evidence of 1
- Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies — Systematic review, 2018
To explore effects of the brain renin-angiotensin system (RAS) on cognition. Systematic review of experimental (non-human) studies assessing cognitive effects of RAS peptides angiotensin-(3-8) [Ang IV] and angiotensin-(1-7) [Ang-(1-7)] and their receptors, the Ang IV receptor (AT4R) and the Mas receptor. Of 450 articles identified, 32 met inclusion criteria. Seven of 11 studies of normal animals found Ang IV had beneficial effects on tests of passive or conditioned avoidance …
Evidence digest
What the research on Dihexa actually shows
The indexed literature on Dihexa includes human clinical or observational records (1 human-clinical or observational record). This digest describes the shape of that evidence and links the records behind it. It does not judge whether Dihexa is safe or effective for any purpose, and nothing here is medical advice — the material sold by the vendors in this index is labeled for laboratory research use only.
3 things the literature does not establish →
PepIndex describes what literature exists. We do not interpret it, assess clinical significance, or publish quantities, protocols or instructions for use.
Vendor comparison
| Vendor | Score here | Price / mg | Certificates | Mean purity | Label deviation | Get it |
|---|---|---|---|---|---|---|
| Northline LabsISO/IEC 17025 | 85.393% | $8.00 (100%) | 0 | — | — | |
| NeuroLabs Research | 79.386% | $7.50 (94%) | 0 | — | — | |
| American PeptidesISO/IEC 17025 | 73.5100% | $14.00 (175%) | 0 | — | — |
Certificate records
No certificate records are indexed. Either none are published, or those published could not be read without an account.