SNAP-8
DermatologicalAlso known as Acetyl octapeptide-3, Argireline extension
Evidence tier
Some human data
1 human trial
- Researched since
- 2020
- Publications
- 2
- Mean purity
- 99.5%
- Vendors listing
- 4
PeptidePlugs shows the highest mean assayed purity for SNAP-8 at 99.7% across 1 lot record. Purity figures below come from the certificates named in each row.
Score breakdown
The score has two halves: the research base — how long the compound has been studied and how much has been published — and the quality of the evidence the market produces for it, aggregated across every vendor that carries it: assayed purity, lot-to-lot consistency, readable third-party certificates and those vendors’ review record. It measures the evidence base, not the merits or safety of the substance.
Studied since 2020 — 6 years of published research
How long the compound has been studied. Fifteen years or more of published literature earns full marks; a newer compound earns less.
2 publications indexed in PubMed
The volume of published literature located. Full marks at fifty or more publications.
Mean assayed purity 99.5% across 3 certificates
Average assayed purity on the certificates published by vendors that carry this compound. Full marks at 99.5%+, nothing at 95% or below.
±0.30 pts purity across lots, mean label deviation 8.1%
How tightly assayed purity and labeled-versus-actual mass hold across different lots. Rewards reproducible manufacturing.
4 of 4 listing vendors publish an accessible certificate policy
Whether the vendors carrying this compound publish per-lot certificates anyone can read without an account.
2 of 3 certificates from a recognised independent lab
Share of certificates issued by a recognised third-party testing lab rather than an unnamed or self-named one.
What is SNAP-8?
An eight–amino-acid peptide extension of the cosmetic peptide argireline, studied topically in relation to the appearance of expression lines.
Studied in published research for the cosmetic appearance of expression lines.
Regulatory status
Labeled by vendors for laboratory research use only. Not approved as a medicine in the United States, United Kingdom, or European Union.
What the research examines
The areas of published research this compound appears in. These describe what the literature has studied — never a claim of benefit, effect or suitability for any use.
Published research
Published work is largely in vitro and in cosmetic formulation research. PepIndex does not evaluate clinical significance and does not describe administration.
- Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities — Annals of dermatology (2024)
Peer-reviewed article indexed in PubMed, published in Annals of dermatology (2024).
- Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study — Journal of cosmetic dermatology (2020)
Peer-reviewed article indexed in PubMed, published in Journal of cosmetic dermatology (2020).
Indexed studies1 human-evidence of 1
- Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study — Human — controlled trial, 2020
Aging skin is a gradual physiological process associated with functional and structural changes of the skin. Both intrinsic and extrinsic factors influence skin aging by the involvement of multiple pathways. Restoring natural skin conditions requires a multi-targeted approach. Recent developments in both bioactive peptides and microneedle delivery system have presented an opportunity for tackling premature skin aging. This study was aimed at evaluating the dermal tolerability…
Evidence digest
What the research on SNAP-8 actually shows
The indexed literature on SNAP-8 includes human clinical or observational records (1 human-clinical or observational record). This digest describes the shape of that evidence and links the records behind it. It does not judge whether SNAP-8 is safe or effective for any purpose, and nothing here is medical advice — the material sold by the vendors in this index is labeled for laboratory research use only.
3 things the literature does not establish →
PepIndex describes what literature exists. We do not interpret it, assess clinical significance, or publish quantities, protocols or instructions for use.
Vendor comparison
| Vendor | Score here | Price / mg | Certificates | Mean purity | Label deviation | Get it |
|---|---|---|---|---|---|---|
| PeptidePlugs | 89.790% | — | 1 | 99.7% | 6.8% | |
| American PeptidesISO/IEC 17025 | 79100% | $5.50 (138%) | 0 | — | — | |
| Evo Labs Research | 75.789% | $4.00 (100%) | 2 | 99.4% | 8.7% | |
| Good Science Bio | 74.775% | $3.50 (88%) | 0 | — | — |
Certificate records
| Vendor | Lot | Tested | Lab | Labeled | Assayed | Discrepancy | Purity | Source |
|---|---|---|---|---|---|---|---|---|
| PeptidePlugs | 141-01-DK | Freedom Diagnostics Testing | 10 mg | 9.32 mg | 6.8% | 99.7% | Vendor-published | |
| Evo Labs Research | EVO5212026 | Kovera Labs | 10 mg | 11.57 mg | 15.7% | 99.7% | Vendor-published | |
| Evo Labs Research | 201125 | Evolabs Research | 10 mg | 10.17 mg | 1.7% | 99.1% | Vendor-published |