Research
Study index
Every study PepIndex has recorded, stored once and referenced from wherever it is relevant. Each carries its evidence type, the model it used, its sample size where reported, and what it found — including null results, which are recorded rather than quietly dropped. Each has a permalink, so a study can be cited without being retyped.
- Studies indexed
- 102
- Human evidence
- 97
- Preclinical only
- 5
| Study | Evidence type | Compounds | Model | n | What it reported | Source |
|---|---|---|---|---|---|---|
| Long-term observational study of afamelanotide in 115 patients with erythropoietic protoporphyriaThe British journal of dermatology · 2015 | Human — observational | Melanotan I | Not recorded | — | In erythropoietic protoporphyria (EPP), an inherited disease of porphyrin-biosynthesis, the accumulation of protoporphyrin in the skin causes severely painful phototoxic reactions. Symptom prevention was impossible until recently when afamelanotide became available. Afamelanotide-induced skin pigmentation has statistically significantly improved light-tolerance, although the clinical significance of the statistical effect was unknown. To assess clinical effectiveness by recor… | PMID 25494545 |
| A glimpse into the underground market of melanotanDermatology online journal · 2018 | Human — observational | Melanotan II | Not recorded | — | Melanotan-I and melanotan-II are alpha-melanocyte stimulating hormone (a-MSH) analogues that can be purchased illicitly online with relative ease and are injected subcutaneously to stimulate a tan. Little is known about the use of these unregulated substances. An observational survey was posted to an online forum in which participants share their experiences using melanotan-I or melanotan-II. Users were asked to complete this voluntary, anonymous survey, which had questions f… | PMID 30142729 |
| Effects of Glucagon-Like Peptide-1 Receptor Agonists, Sodium-Glucose Cotransporter-2 Inhibitors, and Their Combination on Neurohumoral and Mitochondrial Activation in Patients With DiabetesJournal of the American Heart Association · 2025 | Human — observational | MOTS-c | Not recorded | — | We investigated the effects of the combined treatment with glucagon like peptide-1 receptor agonists (GLP-1RA) and sodium-glucose cotransporter-2 inhibitors (SGLT-2i) on NT-proBNP (N-terminal pro-brain natriuretic peptide), GDF-15 (growth differentiation factor 15), and MOTS-c (mitochondrial-derived peptide-c) in patients with type 2 diabetes (T2D) and high or very high cardiovascular risk. We studied 163 consecutive patients with type 2 diabetes who were treated with insulin… | PMID 40008510 |
| Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast CancerCurrent radiopharmaceuticals · 2024 | Human — observational | MOTS-c | Not recorded | — | Lung and breast cancer are the most frequent causes of death from cancer globally. The objectives of this research were to evaluate the serum mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) and humanin levels in lung or breast cancer patients, and investigate the impacts of radiation therapy on the circulating levels of these peptides. 35 lung cancer patients, 34 breast cancer patients, and healthy volunteers as a control group were recruited in this prospective o… | PMID 38314601 |
| Predictive factors of the presence of pulmonary embolism in patients with interstitial lung disease: Observational studyMedicine · 2024 | Human — observational | Selank | Not recorded | — | In patients with interstitial lung disease (ILD), the risk of pulmonary embolism (PE) is increased; however, distinguishing between PE and ILD exacerbation can be difficult. Therefore, this study investigated the usefulness of the Wells criteria and revised Geneva score and predictive factors for diagnosing PE in ILD patients with worsening respiratory symptoms. We retrospectively collected the data of 65 patients with ILD who underwent computed tomography pulmonary angiograp… | PMID 38181286 |