Research
Study index
Every study PepIndex has recorded, stored once and referenced from wherever it is relevant. Each carries its evidence type, the model it used, its sample size where reported, and what it found — including null results, which are recorded rather than quietly dropped. Each has a permalink, so a study can be cited without being retyped.
- Studies indexed
- 102
- Human evidence
- 97
- Preclinical only
- 5
| Study | Evidence type | Compounds | Model | n | What it reported | Source |
|---|---|---|---|---|---|---|
| Managing fatigue in sarcoidosis - A systematic review of the evidenceChronic respiratory disease · 2017 | Systematic review | ARA-290 | Not recorded | — | Fatigue is a common manifestation of sarcoidosis, often persisting without evidence of disease activity. First-line therapies for sarcoidosis have limited effect on fatigue. This review aimed to assess the treatment options targeting sarcoidosis-associated fatigue. Medline and Web of Science were searched in November 2015; the bibliographies of these papers, and relevant review papers, were also searched. Studies were included if they reported on the efficacy of interventions… | PMID 27507833 |
| The time to develop treatments for diabetic neuropathyExpert opinion on investigational drugs · 2021 | Systematic review | ARA-290 | Not recorded | — | Diabetic neuropathy is a multifaceted condition affecting up to 50% of individuals with long standing diabetes. The most common presentation is peripheral diabetic sensory neuropathy (DPN). We carried out a systematic review of papers dealing with diabetic neuropathy on Pubmed in addition to a targeted Google search.Search terms included small fiber neuropathy,diffuse peripheral neuropathy, quantitative sensory testing, nerve conduction testing, intra-epidermal nerve fiber de… | PMID 33423557 |
| Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studiesNeuroscience and biobehavioral reviews · 2018 | Systematic review | Dihexa | Not recorded | — | To explore effects of the brain renin-angiotensin system (RAS) on cognition. Systematic review of experimental (non-human) studies assessing cognitive effects of RAS peptides angiotensin-(3-8) [Ang IV] and angiotensin-(1-7) [Ang-(1-7)] and their receptors, the Ang IV receptor (AT4R) and the Mas receptor. Of 450 articles identified, 32 met inclusion criteria. Seven of 11 studies of normal animals found Ang IV had beneficial effects on tests of passive or conditioned avoidance … | PMID 29733881 |
| Effect of omega-3 fatty acids and fish oil supplementation on multiple sclerosis: a systematic reviewNutritional neuroscience · 2021 | Systematic review | Glutathione | Not recorded | — | Background: Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system, resulting in the degradation of the myelin sheath. Diet especially fish oils and omega-3 has been found to play an important role in MS. This work aimed to review the literature systematically for evidence on the effect of omega-3 fatty acids (EPA, DPA and DHA) on MS progression in adults.Methods: The literature search was conducted in PubMed, Oxford, Cochrane, Embase, Intern… | PMID 31462182 |
| Kisspeptin as a predictor of miscarriage: a systematic reviewThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medici · 2023 | Systematic review | Kisspeptin | Not recorded | — | A highly accurate serum marker for predicting viable pregnancy needs to be developed. Recent studies have demonstrated that kisspeptin is a potential biomarker for this purpose. This systematic review evaluated the available data in the literature on the role of kisspeptin as a miscarriage biomarker. A literature search was conducted in the PubMed/Medline, Embase, Web of Science, and Scopus databases using the following keywords: (kisspeptin) AND (miscarriage OR pregnancy los… | PMID 37015836 |
| Kisspeptin and its Current Clinical Status-A Systematic ReviewCurrent medicinal chemistry · 2025 | Systematic review | Kisspeptin | Not recorded | — | Kisspeptin was initially known as metastin for its role in suppressing metastasis in melanoma and breast cancer. Later, based on its ability to stimulate GPR54, its importance in maintaining an intact hypothalamic-pituitary-ovarian axis was recognised, which is the basis for the widespread application of the drug in several conditions such as secondary amenorrhea, regulation of puberty onset, ovarian function, trophoblast invasion, fertility regulation, parturition, and lacta… | PMID 38265397 |
| A systematic review of case series and clinical trials investigating systemic oral or injectable therapies for the treatment of vitiligoSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] In · 2024 | Systematic review | Melanotan I | Not recorded | — | The purpose of this study is to investigate the effectiveness and safety of oral and injectable systemic treatments, such as methotrexate, azathioprine, cyclosporine, tofacitinib, baricitinib, corticosteroids, statins, zinc, apremilast, etc., for treating vitiligo lesions. Databases including PubMed, Scopus, and Web of Science were meticulously searched for studies spanning from 2010 to August 2023, focusing on systemic oral and injectable therapies for vitiligo, using compre… | PMID 38454597 |
| Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic reviewAmerican journal of physiology. Endocrinology and metabolism · 2024 | Systematic review | NAD+ | Not recorded | — | Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide cofactor that is present in cells and in several important biological processes, including oxidative phosphorylation and production of adenosine triphosphate, DNA repair, calcium-dependent secondary messenger and gene expression. The purpose of this systematic review is to examine whether the coenzyme formulae NAD+ and NADH are safe and effective when acting as a supplement to humans. This systematic… | PMID 37971292 |
| Bremelanotide: New Drug Approved for Treating Hypoactive Sexual Desire DisorderThe Annals of pharmacotherapy · 2020 | Systematic review | PT-141 | Not recorded | — | Objective: To review data regarding bremelanotide, a recently approved therapy for hypoactive sexual desire disorder (HSDD). Data Sources: Literature search of Medline, SCOPUS, and EMBASE was performed using the search terms bremelanotide, bremelanotide injection, Vyleesi, and melanocortin 4 receptor agonist between January 1, 1996, and December 15, 2019. Reference lists from included articles were also reviewed for pertinent citations. Study Selection/Data Extraction: We inc… | PMID 31893927 |
| Emerging pharmacotherapies for obesity: A systematic reviewPharmacological reviews · 2025 | Systematic review | Retatrutide | Not recorded | — | The history of antiobesity pharmacotherapies is marked by disappointments, often entangled with societal pressure promoting weight loss and the prevailing conviction that excess body weight signifies a lack of willpower. However, categories of emerging pharmacotherapies generate hope to reduce obesity rates. This systematic review of phase 2 and phase 3 trials in adults with overweight/obesity investigates the effect of novel weight loss pharmacotherapies, compared to placebo… | PMID 39952695 |
| Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Among Adults Without Diabetes : A Systematic Review of Randomized Controlled TrialsAnnals of internal medicine · 2025 | Systematic review | Retatrutide | Not recorded | — | Recent randomized controlled trials (RCTs) have investigated glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual or triple co-agonists for weight loss among adults with overweight or obesity and without diabetes. To assess the efficacy and safety of GLP-1 RAs and co-agonists for the treatment of obesity among adults without diabetes. MEDLINE, Embase, and Cochrane CENTRAL from inception to 4 October 2024. Placebo-controlled RCTs in otherwise healthy participants wit… | PMID 39761578 |
| Comprehensive Review of the Safety and Efficacy of Thymosin Alpha 1 in Human Clinical TrialsAlternative therapies in health and medicine · 2024 | Systematic review | Thymosin Alpha-1 | Not recorded | — | This study aims to assess the safety and efficacy of Thymosin Alpha 1 (Tα1) through a comprehensive narrative review of clinical studies involving over 11 000 human subjects in more than 30 trials. The focus was on Tα1's application in COVID-19, autoimmune conditions, and cancer treatment, with implications for future considerations. We systematically searched articles relevant to critical studies on COVID-19, infectious diseases, cancer, and autoimmune diseases i… | PMID 38308608 |
| Erectile dysfunction: a global review of intracavernosal injectablesWorld journal of urology · 2019 | Systematic review | VIP | Not recorded | — | Data assessing the effectiveness of intracavernosal injections (ICIs) for the treatment of erectile dysfunction (ED) are limited. This study evaluates intracavernosal injectable therapies for ED and reviews available guidelines that inform clinical practice. A systematic search using electronic databases (Medline, Pubmed) was performed for studies investigating injectable management strategies for ED published after 1990. Primary outcome measures were to comparatively evaluat… | PMID 30895359 |