Evidence digest
What the research on Glutathione actually shows
The indexed literature on Glutathione includes human clinical or observational records (4 human-clinical or observational records). This digest describes the shape of that evidence and links the records behind it. It does not judge whether Glutathione is safe or effective for any purpose, and nothing here is medical advice — the material sold by the vendors in this index is labeled for laboratory research use only.
Updated 25 Aug 2026 · 4 studies indexed · 4 human · compound record
- Studies indexed
- 4
- Human evidence
- 4
- Preclinical only
- 0
What is and is not established
What the literature supports
- Human clinical or observational records are indexed for Glutathione (4).
- Published research is indexed back to 1980, with roughly 96,694 PubMed records located.
- It is listed by one or more vendors tracked in this index.
What is NOT established
- This index does not evaluate whether Glutathione is safe or effective for any use.
- Material sold by the vendors indexed here is labeled for laboratory research use only and is not a regulator-approved medicine in that form.
- No dosing, protocol or human-use guidance is provided or implied anywhere in this index.
Studies indexed
2 human — controlled trial · 1 meta-analysis · 1 systematic review
| Study | Evidence type | Model | n | What it reported | Source |
|---|---|---|---|---|---|
| Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical TrialThe journals of gerontology. Series A, Biological sciences and medical sciences · 2023 | Human — controlled trial | Not recorded | — | Elevated oxidative stress (OxS), mitochondrial dysfunction, and hallmarks of aging are identified as key contributors to aging, but improving/reversing these defects in older adults (OA) is challenging. In prior studies, we identified that deficiency of the intracellular antioxidant glutathione (GSH) could play a role and reported that supplementing GlyNAC (combination of glycine and N-acetylcysteine [NAC]) in aged mice improved GSH deficiency, OxS, mitochondrial fatty-acid o… | PMID 35975308 |
| Effectiveness of N-acetylcysteine in autism spectrum disorders: A meta-analysis of randomized controlled trialsThe Australian and New Zealand journal of psychiatry · 2021 | Meta-analysis | Not recorded | — | Currently, pharmaceutical treatment options for autism spectrum disorder are limited. Brain glutaminergic dysregulation is observed in autism spectrum disorder. N-acetylcysteine, which can be converted to glutathione and subsequently release glutamate into the extracellular space, and thus reduce glutamatergic neurotransmission at synapses, is considered a potential drug for autism spectrum disorder treatment. Here, we analyzed the treatment effects of N-acetylcysteine on aut… | PMID 32900213 |
| Effect of omega-3 fatty acids and fish oil supplementation on multiple sclerosis: a systematic reviewNutritional neuroscience · 2021 | Systematic review | Not recorded | — | Background: Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system, resulting in the degradation of the myelin sheath. Diet especially fish oils and omega-3 has been found to play an important role in MS. This work aimed to review the literature systematically for evidence on the effect of omega-3 fatty acids (EPA, DPA and DHA) on MS progression in adults.Methods: The literature search was conducted in PubMed, Oxford, Cochrane, Embase, Intern… | PMID 31462182 |
| Randomized controlled trial of oral glutathione supplementation on body stores of glutathioneEuropean journal of nutrition · 2015 | Human — controlled trial | Not recorded | — | Glutathione (GSH), the most abundant endogenous antioxidant, is a critical regulator of oxidative stress and immune function. While oral GSH has been shown to be bioavailable in laboratory animal models, its efficacy in humans has not been established. Our objective was to determine the long-term effectiveness of oral GSH supplementation on body stores of GSH in healthy adults. A 6-month randomized, double-blinded, placebo-controlled trial of oral GSH (250 or 1,000 mg/day) on… | PMID 24791752 |
Vendors listing Glutathione
The evidence above describes the published literature. What any individual vial contains is a separate question, answered by that vendor’s certificate records rather than by any study on this page.
| Vendor | Score · Coverage | Certificates | |
|---|---|---|---|
| Next Gen Peptides | 93.897% | 2 | profile → |
| Ascend Science | 90.291% | 2 | profile → |
| PeptidePlugs | 89.790% | 2 | profile → |
| Hydro Research Peptides | 88.289% | 1 | profile → |
| Prime Peptides | 87.180% | 1 | profile → |
| American Peptides | 83.6100% | 1 | profile → |
| NeuroLabs Research | 79.386% | 1 | profile → |
| ZC Labs | 79.384% | 2 | profile → |
| Good Science Bio | 79.275% | 0 | profile → |
| Evo Labs Research | 75.789% | 0 | profile → |
| Modern Aminos | 74100% | 1 | profile → |
| Simple Peptide | 7489% | 1 | profile → |
| True Research Labs | 71.971% | 0 | profile → |
| Vertex Labs | 70.170% | 1 | profile → |
| Eternal Peptides | 68.265% | 0 | profile → |
| Mile High Compounds | 65.494% | 0 | profile → |
How to read this page
This digest describes what published research exists and what it does not establish. It is not a recommendation, contains no dosing information or protocols, and makes no claim that any compound is safe or effective for any purpose. Material listed by indexed vendors is labeled for laboratory research use only.